Synthesis and biological activity of 3-azahetarylchroman-4-ones

Authors

  • Natalia Gorbulenko Department of Chemistry, Taras Shevchenko National University of Kyiv, Lva Tolstogo Street, 12, Kyiv 01601, Ukraine
  • Tatyana Shokol Department of Chemistry, Taras Shevchenko National University of Kyiv, Lva Tolstogo Street, 12, Kyiv 01601, Ukraine
  • Vladimir Khilya Department of Chemistry, Taras Shevchenko National University of Kyiv, Lva Tolstogo Street, 12, Kyiv 01601, Ukraine

DOI:

https://doi.org/10.17721/fujcV3I1P4-20

Keywords:

flavonoids, chromones, 3-hetarylchromones, nucleophilic substitution, cyclization, reduction/hydrogenation, 3-hetarylchroman-4-ones

Abstract


Articles reporting on the synthesis and biological activity of 3-hetarylchroman-4-ones are reviewed. The following preparative methods to 3-hetarylchroman-4-ones - nucleophilic substitution in 3-bromochroman-4-ones, cyclization of 2-hydroxy-α-hetarylacetophenones, reduction/hydrogenation of 3-azahetarylchromones, their benefits and disadvantages are described. The biological activity of 3-hetarylchromanones is also surveyed.

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Published

2015-03-10

Issue

Vol. 3 No. 1 (2015)

Section

Review

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